GRAAF, Regnier de. Opera Omnia. Pub. LUGD (Lyon): Sumpt. Io. Ant. Huguetan & Soc, 1678. Engr. title, pp iii-xx, [1] leaf, portrait, 390pp :: many plates. REGNIER DE GRAAF (1641-1673) was a Dutch physician and anatomist who made key discoveries in the biology of the reproductive and digestive tracts. He studied medicine in Utrecht and Leiden, submitted his doctoral thesis on the pancreas, and went to France where he obtained his medical degree from the University of Angers. After returning to the Netherlands, since he was a Catholic in a mainly Protestant country, he was unable to follow a university career. After the early death of a son, De Graaf died in 1673 at age 32. The mature stage of the ovarian follicle is called the Graafian follicle in his honour. De Graaf also described the anatomy of the testicles and collected secretions of the gall bladder and the pancreas (all illustrated in the plates). Full leather binding with later spine and corner restoration. Text block shelf dusted. Contents toned with extensive light foxing and marks, mostly to the margins. Plates not over handled, foxed and toned particularly the top margin. Some extraneous creases. Refer to images. Bookplate: Ex Libris Anatomica K.F. Russell (181x120mm)